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Dr.
James F. Drane
Rusell B. Roth Professor of Clinical Bioethics
Edinboro, University of Pennsylvania (Emeritus)
- Cloning
turns every thinking being into something of a moral philosopher
- Today's
Ethics Experts
- Religious
ethicists
- Scientists
as ethicists
- Business
ethicists
- Literary
ethicists
- Government
ethicists
- Bioethicists
- Some
personal thoughts
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Cloning
turns every thinking being into something of a moral philosopher.
Everyone has an opinion on whether or not it is right to clone
another human being. The idea of asexually producing multiple
copies of genetically identical organisms, all descended from
a common ancestor, creates in most people a negative moral reaction.
Why would anyone want to do such a thing is the response most
often heard by pollsters. But most people also recognize that
once human cloning becomes scientifically possible, it is only
a matter of time until it is done. Should we then just sit back
and accept the inevitable no matter how repulsive it seems or
what the consequences may be? Or should we begin to try to formulate
standards for making morally defensible decisions about this new
scientific possibility?
The initial negative reaction of most people to human cloning
is not unimportant. The 2500 year old philosophical discipline
called Ethics, and the newer discipline called Bioethics, both
take the emotional responses of normally developed human beings
into account when trying to formulate answers to tough ethical
questions. Most people instinctually sense that procreation resulting
from an expression of love and within the context of a family
is something good that should be protected. Most everyone believes
that sexual procreation should not be replaced by some laboratory
technology. All cultures have some ethical standard like the Fourth
Commandment (Honor your father and your mother) or the Sixth (Do
not commit adultery) which gives expression to this basic ethical
sense and which holds up for emulation what today we call family
values.
But instinctual reactions and ancient ethical norms are not all
there is to ethics. Ancient texts cannot be used out of context
as quick solutions to contemporary technical problems without
violating the texts and fooling ourselves. And, although our initial
reaction to a new scientific possibility may be repulsive, examples
abound of changes which initially caused a negative reaction and
later came to be accepted because they produced important good
consequences. One of the roles of the ethicist, or moral philosopher,
is to consider all aspects of an issue; consequences and circumstances,
purposes and possibilities. Ethics means thinking hard and long
about issues and not relying exclusively either on important verses
for scripture or important initial instinctual responses.
Today's
Ethics Experts
Many
people today qualify as practitioners of serious ethical reflection.
Most priests, preachers, and rabbis consider themselves ethicists.
Journalists also do, especially editorial page journalists. Even
electronic journalists turn into ethicists after they retire (e.g.
Walter Cronkite and David Brinkley). Doctors act as major ethicists
in our culture, telling us daily on TV and in the newspapers how
to live, how to die, how to raise children, what to eat, and on,
and on. Every discipline in fact produces its own ethicists. Readers
of editorial pages will not be surprised by the many "expert"
ethical commentaries on today's big ethical issue of cloning.
Religious
ethicists
The
greatest number of ethics experts comes out of religion. Vatican
ethicists have already taken a strong stand against cloning thereby
continuing a sad history of negative overreaction to scientific
discovery. Bishop Sgreccia declared that it is wrong to alter
an animal species, let along a human being. Another spokesman
talked about cloning as a violation of the integrity of marriage.
Vatican experts reflect the Pope's views and he has already rejected
any use of technology which interferes with sexual procreation
within marriage or makes it likely that human embryos would be
destroyed.
Catholic theologians may use different background assumptions
from the Pope and their opinions tend to be more nuanced. Some
see genetic technologies as an expression of human creativity
and human creativity as a good because it reflects God's creativity.
Making new plants and animals by genetic interventions is widely
defended theologically but still most Catholic moralists draw
a line at human cloning.
Protestant ethicists tend to look for insights from scripture.
Scripture however does not provide specific answers to modern
problems. It can provide general ethical direction which then
has to contend with contradictory direction coming from different
texts. The book of Genesis for example provides us with two different
creation stories. In the first (Genesis, chapter one), man is
protrayed as having dominion over all creation. By exercising
dominion, man would be acting in God's image. This story might
support genetic technologies and even cloning. In the second creation
story (Genesis, chapter two), man's role is more that of steward.
He is to care for creation and protect it. Now the ethical direction
would be just the opposite and cloning might be considered a violation
of stewardship. Scripture is an important source of ethical direction
for all Judeo-Christian religious people, but since scripture
provides no specific answers to contemporary scientific problems,
biblical ethicists have to think through the issue of cloning
very much like all others do.
Jewish ethicists tend to look for ethical direction both from
scripture and from the Talmud (Jewish law and tradition). Rabbi
Moses Tendler, a professor of medical ethics, looked at cloning
using the talmudic metaphor of the bee which offers both honey
and a sting. Are we, he asked, at the point on the tree of knowledge
where we'd rather give up the honey to avoid the sting? Other
rabbis saw no reason to criticize or even to regulate cloning.
Scientists
as ethicists
Most
religious ethicists consider human cloning to be wrong. The most
permissive among them urge great caution in using this kind of
genetic manipulation. Science however has its own ethicists and
generally they take the opposite view. Scientists tend to focus
on the positive benefits of cloning and discount the dangers.
They tend to take predictions of catastrophic consequences seriously.
Ethical criticism from outside science they tend to see as unenlightened
and/or prejudicial. Scientists can be trusted to do their own
ethics, they claim. They even have their own ethical heroes, scientific
saints of sorts (Galileo, Bacon).
Science's ethicists emphasize the possibilities of conquering
disease and infertility. They focus on new information about cell
functioning which will aid in the fight against cancer. Cloning
might also protect against certain genetic diseases which result
from combining genes from both parents. But science has its own
history of ethical scandals and the idea that people should just
let scientists do what they think is right, convinces almost no
one. Dr. James Watson, who won the Nobel Prize for discovering
the structure of DNA, agreed that this issue could not be left
to science.
Business
ethicists
If
science doesn't like ethical restrictions, neither does business.
Spokespersons for business interests (in the Economist)
lined up with scientists against any talk about restricting cloning.
Business interests are more concerned about animal than about
human cloning. They do not want the business possibilities of
cloning animals to be ruined by worries about human cloning.
Literary
ethicists
Literature,
like religion, is an important source of ethics. Novelists and
poets provide ethical viewpoints and several have already taken
very critical stands on cloning. Mary Shelly's novel "Frankenstein"
(1818) was the first such negative evaluation. Shelly's Frankenstein
was intelligent and articulate, but deeply anguished by his unnatural
origin. In this story, he goes mad with grief and murders the
doctor who made him. "The Boys from Brazil" was just as frightening
a take on cloning.
Government
ethicists
Through
the influence created by its funding, the government has for years
required strict ethical controls over genetic research and therapy
involving human beings. Immediately after the recent cloning news,
President Clinton temporarily banned the use of federal money
for human cloning experiments. Not long after the President's
decree, one Republican Congressman (Representative Vernon Elders
of Michigan) proposed a ban on human cloning because it might
create a negative reaction to animal cloning and thereby hurt
business. No telling what congress will do, but even if the government
prohibits cloning, it sitll leaves the marketplace as an alternative
base for cloning activities.
Bioethicists
Bioethicists
are relativeliy new players on the broad stage of ethical reflection.
Bioethics has its own background theories and abstract principles
and paradigm stories, but it moves from these broad ethical perspectives
to concrete norms and rules and policies. What we expect from
bioethics is less inspiration and more practical guidelines for
what we can and cannot do in science and medicine.
Bioethicists have been at work in the area of genetics since shortly
after the discovery of DNA. They make a distinction between somatic
cell and germline cell genetic interventions. The former refers
to treatments of genetic disease by introducing a properly functioning
gene into one person in whom that gene is defective. It focuses
on diseases like Tay Sachs, Lesch Nyham, and Sickle Cell Anemia.
Somatic cell therapy affects only the person suffering from a
recognized genetic disease. It is distinguished from germline
therapy which involves changes in an ovum or sperm and therefore
involves gene alterations which will be passed down to other generations.
Here is an example of bioethical standards or guidelines for somatic
cell gene interventions on human beings.
- Genetic
intervention can be used only for the treatment of a serious
genetic disease.
- No
alternative, non-genetic therapy, is available.
- The
genetic defect must be clearly identified.
- Extensive
animal studies must precede any human interventions in order
to support claims of safety and effectivenes.
- All
therapuetic interventions must be preceded by elaborate informed
consent procedures.
- Consent
forms and strategies must be approved by an institutional ethics
committee.
Cloning would be an example of germline genetic intervention.
It is more difficult to get approval for germline interventions
for many reasons, including the fact that germline cell alterations
are difficult to transfer and therefore have limited effectiveness.
(It took hundreds of tries to clone Dolly). Germline ethical standards,
added to the above mentioned ones, are more stringent:
- The
genetic science must be proven and the proposed intervention
must have a reasonable success rate.
- The
germline intervention must hold the promise of substantial usefulness.
- No
intervention is ethically permitted which alters fundamental
human characteristics; e.g. freedom, intelligence, and relational
capacity.
- No
intervention is ethically permitted which might create a risk
to the gene pool or to genetic diversity.
All the presently in-place bioethical guidelines would militate
against approval of cloning at the present time. The recent cloning
of sheep and monkeys make successful human cloning almost a certainty
and overcomes an objection based on lack of success. But would
human cloning offer substantial usefulness? Dr. Ian Wilmut, who
cloned the lamb, expressed opposition to human cloning. People
are not thinking carefully, he said, and he could see no useful
application of his cloning techniques to humans.
Dr. Wilmut's ethical reservations about human cloning might also
be based on criterion 3. Human cloning certainly alters the basic
relationship between the cloned person and the "parent" (genetic
ancestor). And any extensive use of cloning would violate guideline
4 by creating a risk to the gene pool and gentic diversity.
The present limited therapeutic applications of cloning make it
likely that cloning would be done in order to make design changes
in the human species (eugenics). But how do we decide what changes
in the human species are appropriate? What sort of persons should
we be? Should we enhance the human condition? Should we become
our own creators? These important issues explain why Dr. James
Watson (the discoverer of DNA) couldn't justify leaving ethical
questions about cloning to scientists.
Medical science and genetic technology now force all of us to
face the basic questions: What is human life? What is a child?
Who is a parent? What is a family? What is the purpose of having
children? Is there a God? Are we our own creators or stewards
of God's creation? No one has the definitive answer to any of
these questions. We humans must go on questioning. The struggle
for meaning is never over. Only religious and secular fundamentalists
are sure they have the answers. Certain things, however, we could
all agree about. Human beings are creative. Inevitably we intervene
into nature with our tools and technologies. But we ought to respect
nature's structure and go slowly into an area so delicate as human
cloning.
Some
personal thoughts
Bioethicists
like all other professional moralists have to start thinking much
more seriously about cloning now. Human cloning has not been given
much attention because it was not considered possible and too
many other problems needed solutions. All this has changed.
Bioethics can start by clearing the table of obvious mistakes
and false problems. Cloning produces a genetic copy but not a
xeroxed person. A genetic clone is a different person who will
have a different environment, different opportunities, different
luck, different choices, a different spirit or soul. A cloned
Einstein could wind up using his superior intelligence to create
a world wide drug ring. Free will is not cloned. Environment,
especially family environment, is still a major influence on the
persons we become. A cloned child may wind up being very different
from the sibling from whom he or she was cloned just because of
the influence of place in the family. Clones will look alike,
but they won't have the same experience and therefore will be
different. We know this to be true from what we know about monozygotic
twins who are nature's clones.
On the other hand, any serious ethical consideration of cloning
has to take into consideration the fact that human beings have
a capacity for both good and evil. Neither possibility can be
discounted. As genetic science advances many goods from cloning
may emerge. But even objective goods can be undermined by evil
human attitudes and dispositions. Narcissistic personalities could
use cloning to indulge their sick egocentric selves or to engineer
their own versions of immorality. Envious and greedy people would
use cloning to make money. Power crazy types would use cloning
to increase domination over others. The human potential for evil
is real and cannot be left out of considerations about the ethics
of cloning.
Would it be too naive to suggest that scientists and theologians
and bioethicists start working together to develop ethical guidelines
for cloning rather than just banning the whole idea? After all,
the founder of genetics was a Catholic priest. Father Gregor Mendel
discovered genes and his research in genetics is still valid nearly
150 years later. There was no inherent conflict then between ethics,
religion, and genetic science. The lesson of Gregor Mendel is
that religion and genetics are not incompatible. Instead of suspicion
or prejudice or knee-jerk negative reactions, couldn't genetic
scientists and bioethicists and theologians start out by developing
ethical standards ordinary people would feel comfortable with?
Lest this sound too mushy, a Presidential Ethics Commission is
already formed and promises to provide some recommendations in
90 days. Hopefully that commission will be aware of history. Mistakes
have been made in the past. Horrible evils have taken place. Millions
of innocent persons have lost their lives to superficial and myopic
theories about how the human species should be genetically improved.
We are too ignorant about how the tightly interrelated elements
in the ecosystem operate to climb aboard eugenic proposals. It
would be an insult to the millions of innocent victims of Nazi
eugenic programs if those who set the ethical standards for genetic
research and interventions could not at some point say no.
 
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