RAKIDUAM - Knowledge

The Institute of Biomedical Neuroscience (BNI) is part of a node of cutting-edge research that is of global interest. It studies the entire nervous system, from molecules to organisms in multiple animal models. For this reason, it uses a combination of biological and mathematical approximations to maximize the collection of information from living beings. In addition, the research focuses on neu- rological and psychiatric pathologies. Its studies seek to understand the contribution of components of the cytoskeleton and subcellular traffic in the nervous system in order to know how these determine neuronal function or dysfunction; how the expression of genes conditions the morphofunctional characteristics throughout the deve- lopment and useful life of the neurons. Also, in what way the activity of the genes translates into the morphogenesis of the brain; how genetic interactions and signaling pathways control lasting memo- ries; how the neuronal activity associated with cognitive functions is organized during “ecological” functions and how the genes associated with illnesses affect common cellular and physiological processes, such as for example the synaptic function, developing technological and therapeutic approaches. We are interested in learning about the nervous system and its functioning in depth, which will con- tribute towards showing who human beings are and towards understanding the causes of the neu- rological and psychiatric illnesses that affect them. Also, we seek to share this enthusiasm and its impact on society. Principal Institution: Universidad de Chile. Associated Institutions: none. Institute of Biomedical Neuroscience (BNI) 23 Lines of Research Functional sub-cellular dynamics. Cellular identity and morphology. Supra-cellular circuit development. Plasticity and behavior. Systems Neuroscience. Applied mathematics and biomedical IT. Neural dysfunction and pharmacological targets. Clinical research and creation of new skills.