Alteraciones neuro-funcionales en trastornos del ánimo que cursan con conductas auto-mutilatorias: estudio de perfusión regional cerebral a partir de la técnica de Neuro-SPECT Tc99-HMPAO.

Abstract.

We report NeuroSPECT findings in mood disorders, including bipolar disorder, major depression and self-mutilation. We compare results in 29 patients with bipolar disorder complicated by self-mutilation, a group of 20 patients with bipolar disorder uncomplicated and 22 patients with mayor depression uncomplicated by self-mutilation. Among the NeuroSPECT findings we report the association of mood disorders and self-mutilation with hyperperfusion of the anterior-dorsal-ventral segment of both thalami concomitant with hypoperfusion in perilimbic cortex, namely areas 32, 24 (anterior cingulate gyrus) and 23 of Brodmann. Multiple reports in the literature relate both, in animals and man, self-mutilation with phenomena of hypoalghesia, anesthesia, or dysestesias  and are the basis for our hypothesis linking dysfunction of limbic-thalamic circuits, associated with nocioceptive fibers, somato-psychic consciousness and self-mutilation phenomena.

Resumen | Abstract. | Introducción | La auto-mutilación como fenómeno clínico de orden complejo: concepto y generalidades | Aspectos clínicos en auto-mutilación | Etiología de los fenómenos auto-mutilatorios | Correlación entre auto-mutilación y percepción alterada del dolor | Descripción del estudio | Resultados | Conclusiones y Discusiones | Bibliografía | Print